| Name | Character | Episodes |
|---|---|---|
| Sharon Stone | Lenore Osgood | 8 |
| Vincent D'Onofrio | George Wilburn | 8 |
| Sarah Paulson | Mildred Ratched | 8 |
| Cynthia Nixon | Gwendolyn Briggs | 8 |
| Jon Jon Briones | Richard Hanover | 8 |
| Corey Stoll | Charles Wainwright | 8 |
| Finn Wittrock | Edmund Tolleson | 8 |
| Judy Davis | Betsy Bucket | 8 |
| Charlie Carver | Huck | 8 |
| Amanda Plummer | Louise | 8 |
| Alice Englert | Dolly | 8 |
| Alfred Rubin Thompson | Albert Alton | 4 |
| Sophie Okonedo | Charlotte Wells | 3 |
| Rosanna Arquette | Anna | 2 |
| Daniel Di Tomasso | Dario Salvatore | 1 |
| Robert Curtis Brown | Monsignor Sullivan | 1 |
| Hunter Parrish | Father Andrews | 1 |
| David Wells | Father Murphy | 1 |
| Jermaine Williams | Harold | 1 |
| Kirk Bovill | Prison Representative | 1 |
| Wes Armstrong | Daniel | 1 |
| Aaron Jay Rome | Photographer #2 | 1 |
| Brian Maillard | Father Coleman | 1 |
| Damien Luvara | Bartender | 1 |
| Patrick Duke Conboy | Burly Man | 1 |
| Clayton Farris | Reporter #1 | 1 |
| Jim Bentley | Maitre D' | 1 |