| Name | Character | Episodes |
|---|---|---|
| John Goodman | Michael Ennis | 8 |
| Tamara Tunie | Eunice Clayton | 8 |
| Michaela Coel | Kate Ashby | 8 |
| Emmanuel Imani | Florence Karamera | 8 |
| Noma Dumezweni | Alice Munezero | 8 |
| Lucian Msamati | David Runihura | 8 |
| Abena Ayivor | President Bibi Mundanzi | 8 |
| Tyrone Huggins | Patrice Ganimana | 8 |
| Treva Etienne | Frank Munezero | 5 |
| Nicholas Beveney | Nkanza a Nkanga | 5 |
| Adrian Schiller | Daniel Drewe | 4 |
| Paul Herzberg | Zava Zand | 4 |
| Michael Gould | Harper Hopkinson | 4 |
| Julian Glover | Mark Viner | 3 |
| Serge Hazanavicius | Marc Previeau | 3 |
| Ronald Guttman | Jacques Antoine Barré | 3 |
| Nancy Crane | Judge Deborah Hewitt | 3 |
| Timothy Walker | Richard Ratzenburger | 3 |
| Kathryn Hunter | Capi Petridis | 2 |
| Wale Ojo | Dr. Emmanuel Musoni | 2 |
| Harriet Walter | Eve Ashby | 2 |
| Olivier Rabourdin | Brigadier General Lesage | 2 |
| Aure Atika | Sophie Barré | 2 |
| Danny Sapani | General Simon Nyamoya | 2 |
| Mimî M. Khayisa | Mary Mundanzi | 2 |
| Françoise Lebrun | Madame Florence Patenaude | 2 |
| Philip Arditti | Colonel Colbert | 2 |
| Hugo Blick | Blake Gaines | 2 |
| Martin Bassindale | Peter | 2 |
| Zaris-Angel Hator | Young Kate | 2 |
| James Lailey | Michael's Surgeon | 2 |
| Nyasha Hatendi | Godwin Hall | 2 |
| Agathe de La Boulaye | Stephanie Hubert | 1 |
| Sule Rimi | Dr. Busasa | 1 |
| Paapa Essiedu | Jaalen | 1 |
| Frances Tomelty | Sorcha Beattie | 1 |
| Larrington Walker | Pastor Thomas | 1 |
| Adrian McLoughlin | Cyclist | 1 |
| Nigel Whitmey | Major Charles Bouchard | 1 |
| Yolanda Vazquez | Judge Catalina Teixeira | 1 |
| Ronkẹ Adékoluẹjo | Alice's Secretary | 1 |
| Serge Soric | Clinician Jure Sutalo | 1 |
| Paul Clayton | Jack Marshall | 1 |
| Elliot Levey | Consultant Jacob Sayers | 1 |
| Alain Azerot | Lieutenant Frank Makuze | 1 |
| Matthew Steer | Charles Barrett | 1 |
| Mark Underwood | John Newfield | 1 |
| Paul Birchard | Andrew McCulloch | 1 |
| Robin Weaver | Detective | 1 |