| Mixels are mischievous creatures who live in tribes of three. They have the ability to combine with other Mixels, either within a single tribe or cross-combining to gain another tribe's abilities. All that is needed to combine are willing Mixels and a magical square known as a cubit. The colorful creatures have to look out for Nixels, who consider themselves superior and like to destroy Mixel combinations. Major Nixel, the group's leader, throws and kicks his underlings to steal cubits. |
| Name | Character | Episodes |
|---|---|---|
| Phil LaMarr | Flurr, Chomly, Tentro | 22 |
| Fred Tatasciore | Slumbo, Jawg, Kraw, Major Nixel, Nixels | 22 |
| Jess Harnell | Vulk, Shuff, Zaptor | 22 |
| Tom Kenny | Flain, Seismo, Teslo | 22 |
| Billy West | Lunk, Gobba, Balk | 22 |
| David P. Smith | Zorch, Krader, Volectro | 22 |
| Jeff Bennett | Dribbal, Gurggle, Jinky | 1 |
| Jeff Bennett | Camillot, Ranger Jinx | 1 |
| Peter Jason | Major Nixel, Tuth, Sharx | 1 |
| Peter Jason | Major Nixel, Turg, Wuzzo | 1 |
| Cree Summer | Jamzy, Teacher | 1 |
| Rodger Bumpass | Flamzer, Naut, Major Nixel | 1 |
| Daran Norris | Snoof, Waka, Spugg | 1 |
| Daran Norris | Tiketz | 1 |
| Steve Blum | King Nixel, Kamzo | 1 |
| Steve Blum | King Nixel, Spinza, Aquad | 1 |
| Jess Harnell | Burnard, Meltus | 1 |
| Jess Harnell | Zabo, Hydro, Surgeo | 1 |
| Jess Harnell | Vaka | 1 |
| Dave Fennoy | Krog, Kramm | 1 |
| Dave Fennoy | King | 1 |
| Dave Fennoy | Globert, Boogly | 1 |
| Chris Cox | Busto, Principal | 1 |
| Chris Cox | Gox, Forx | 1 |
| Tom Kenny | Booger | 1 |
| Tom Kenny | Berp, Tungster | 1 |
| Tom Kenny | Booger, Screeno, Mysto | 1 |
| Richard Steven Horvitz | Mixadel | 1 |
| Richard Steven Horvitz | Scrud, Splasho | 1 |
| Andrew Kishino | Niksput | 1 |
| Sam Riegel | Vampos | 1 |
| Leonard R. Garner, Jr. | Cobrax | 1 |