| Name | Character | Episodes |
|---|---|---|
| Noah Huntley | Professor Donovan Osborn | 23 |
| Vikash Bhai | Professor Martin Shral | 23 |
| Ben Radcliffe | Ralen Maht | 23 |
| Tina Casciani | Tierney | 23 |
| Manu Bennett | Leone Vokk | 13 |
| Raechelle Banno | Atria Nine | 13 |
| Martin Bobb-Semple | Thomas James Ross | 13 |
| John Harlan Kim | Greg Li | 13 |
| Banita Sandhu | Delaney Pilar | 13 |
| Tehmina Sunny | Regan Fried | 13 |
| Tommie Earl Jenkins | Professor Ellison Pevney | 13 |
| JR Esposito | The Courier | 10 |
| Luke Fetherston | Harlan Fried Jr. | 10 |
| Isabelle Bonfrer | Cordelia Fried | 5 |
| Ben Cross | Harlan Fried | 4 |
| Luke Fetherston | Younger Harlan Fried | 4 |
| Jonathan Kerrigan | Seeker Creston Hubbell | 3 |
| Johann Urb | Captain Jaworski | 2 |
| Lola Ogunyemi | Kossara | 2 |
| Charisma Carpenter | Eve | 1 |
| Sophie Robertson | Magda Coy | 1 |
| Jeffrey Combs | Berman Livingston | 1 |
| Maryam d'Abo | Maya Fleming | 1 |
| Ana Alexander | Phobus | 1 |
| Erin Gray | Captain Beth Grant | 1 |
| Charlotte Salt | Norris | 1 |
| Dino Kelly | Lt. Cade Collins | 1 |
| Angélica Celaya | Pandora | 1 |
| Andi Osho | Rosa Ross | 1 |
| Douglas Reith | Prescott Fleming | 1 |
| Alexander Hanson | Nelson Fisk | 1 |
| Daniel Feuerriegel | Devlin | 1 |
| Richard Blackwood | Billy Dwayne Ross | 1 |
| Nathan Cooper | Academy Librarian | 1 |
| Karina Banno | Atria Three | 1 |
| Mercer Boffey | Bennings | 1 |