| Name | Character | Episodes |
|---|---|---|
| Helen Hunt | Jamie Buchman | 12 |
| Anne Ramsay | Lisa Stemple | 12 |
| Richard Kind | Dr. Mark Devanow | 12 |
| Paul Reiser | Paul Buchman | 12 |
| John Pankow | Ira Buchman | 12 |
| Abby Quinn | Mabel Buchman | 12 |
| Antoinette LaVecchia | Lucia Francavella | 9 |
| Sofia Hasmik | Ashta | 4 |
| Kimia Behpoornia | Yasmeen | 3 |
| Asif Ali | Rishi | 3 |
| Mo Gaffney | Dr. Sheila Kleinman | 3 |
| Christopher Meyer | Lucas Cooper | 2 |
| Jerry Adler | Mr. Wicker | 2 |
| Cynthia Harris | Sylvia Buchman | 2 |
| Jean Smart | Chelsea Stevens-Kobolakis | 1 |
| Jason Alexander | Jason Alexander | 1 |
| Jennifer Westfeldt | Donna Lawson | 1 |
| Stacey Swift | Tina | 1 |
| Layla Mohammadi | Meg Martin | 1 |
| Tarina Pouncy | Justine | 1 |
| Carol Burnett | Theresa Stemple | 1 |
| Tracie Thoms | Dean Calhoun | 1 |
| Cloris Leachman | Mrs. Mandelbaum | 1 |
| Beau Billingslea | Ralph Martoni | 1 |
| Todd Sherry | Todd | 1 |
| Christina Marie Karis | Mara Buckland | 1 |
| Paul Eiding | Herbert | 1 |
| Blake Cooper Griffin | Aaron | 1 |
| Todd Grinnell | Jon Dale | 1 |
| Peter Tolan | Customer | 1 |
| Ungela Brockman | Film Professor | 1 |
| Marc Grapey | Hercules Schlein | 1 |
| Kinna McInroe | Patty | 1 |
| Daniele Gaither | Janelle | 1 |
| Maurice J. Irvin | Fantasy Coffee Husband | 1 |
| Andréa Burns | Dean Warren | 1 |
| Frederick Dawson | Catheter Spokesman | 1 |
| Greta Jung | Yung Hee | 1 |
| B.J. Ward | Announcer (voice) | 1 |
| Ursula Brooks | House (voice) | 1 |
| Carrie Aizley | Nancy | 1 |
| Amaris Dupree | Health Inspector | 1 |
| Jeff Garlin | Marvin | 1 |