| Name | Character | Episodes |
|---|---|---|
| Jessica Fox | Nancy Osborne / Nancy Hayton / Nancy Dean | 6537 |
| Guy Burnet | Craig Dean | 6528 |
| Tony Hirst | Mike Barnes | 1826 |
| Nikki Sanderson | Maxine Minniver | 1570 |
| Mandip Gill | Phoebe Jackson / Phoebe McQueen | 1045 |
| Anna Shaffer | Ruby Button | 1044 |
| Anna Passey | Sienna Blake | 1042 |
| Wallis Day | Holly Cunningham | 523 |
| Rukku Nahar | Asha Kaur | 261 |
| Lauren McQueen | Lily Drinkwell | 260 |
| Jessica Fox | Nancy Osborne | 6 |
| Badria Timimi | Doctor Abraham | 2 |
| Rita Simons | Marie Fielding | 2 |
| Sherrie Hewson | Martha Blake | 2 |
| John Weaver | Student | 2 |
| Fabienne Piolini-Castle | Justine | 2 |
| Christian Ealey | Matt Musgrove | 2 |
| Rebecca Root | Midwife | 1 |
| Scott Mills | Scott Mills | 1 |
| Sonia | Sonia | 1 |
| Suzanne Collins | Nikki Shadwick | 1 |
| Louis Emerick | Donny Clark | 1 |
| Jonathan Howard | PC Gary Hardy | 1 |
| Jeremy Sheffield | Jeremy Blake | 1 |
| Terri Dwyer | Ruth Osbourne | 1 |
| Warren Derosa | Rob Hawthorn | 1 |
| Jeni Howarth Williams | Miss Riley | 1 |