| Pat O’Brien | Dave Logan | 
    
    
      | Beverly Roberts | Jean Logan | 
    
    
      | Ross Alexander | Tom Collins | 
    
    
      | Humphrey Bogart | Hap Stuart | 
    
    
      | Marie Wilson | Sunny Avery | 
    
    
      | Joseph Crehan | Jim Horn | 
    
    
      | Joe King | Mr. Pierson | 
    
    
      | Addison Richards | Mr. B.C. Hill | 
    
    
      | Ruth Robinson | Mother Brunn | 
    
    
      | Henry B. Walthall | Dad Brunn | 
    
    
      | Carlyle Moore Jr. | Radio Operator on Clipper | 
    
    
      | Lyle Moraine | Co-Pilot on Clipper | 
    
    
      | Dennis Moore | Engineer on Clipper | 
    
    
      | Wayne Morris | Navigator on Clipper | 
    
    
      | Alexander Cross | Bill Andrews | 
    
    
      | William Wright | Pilot | 
    
    
      | Kenneth Harlan | Department of Commerce Inspector | 
    
    
      | Anne Nagel | Secretary | 
    
    
      | Marjorie Weaver | Secretary | 
    
    
      | Milburn Stone | Radio Operator | 
    
    
      | Owen King | Radio Operator | 
    
    
      | Irving Bacon | Charlie - the Janitor (uncredited) | 
    
    
      | George Beranger | Waiter (uncredited) | 
    
    
      | John Butler | Second Commerce Inspector (uncredited) | 
    
    
      | Glen Cavender | Pan American Union Waiter (uncredited) | 
    
    
      | Joe Cunningham | Jack - a Weatherman (uncredited) | 
    
    
      | Hal K. Dawson | Airplane Designer (uncredited) | 
    
    
      | Ralph Dunn | Plane Announcer at Miami Airport (uncredited) | 
    
    
      | Bill Elliott | Pilot (uncredited) | 
    
    
      | Frank Faylen | Weatherman (uncredited) | 
    
    
      | Jonathan Hale | State Department Official (uncredited) | 
    
    
      | Jack Hatfield | Reporter (uncredited) | 
    
    
      | Milton Kibbee | Mechanic (uncredited) | 
    
    
      | Shirley Lloyd | Eadie - Horn's Secretary (uncredited) | 
    
    
      | John Marston | Airplane Designer (uncredited) | 
    
    
      | Walter Miller | Instructor (uncredited) | 
    
    
      | Thomas Pogue | Key West Speaker (uncredited) | 
    
    
      | Georges Renavent | Pan American Union Speaker (uncredited) | 
    
    
      | John Graham Spacey | Australian Broadcaster (uncredited) | 
    
    
      | Edwin Stanley | Airplane Designer (uncredited) | 
    
    
      | Houseley Stevenson | Doctor (uncredited) | 
    
    
      | Harland Tucker | Airplane Designer (uncredited) | 
    
    
      | Guy Usher | State Department Official (uncredited) | 
    
    
      | Emmett Vogan | Airplane Designer (uncredited) | 
    
    
      | Pierre Watkin | Secretary of State (uncredited) |