| Name | Character | Episodes |
|---|---|---|
| David Strathairn | Lee Rosen | 24 |
| Laura Mennell | Nina Theroux | 24 |
| Azita Ghanizada | Rachel Pirzad | 24 |
| Warren Christie | Cameron Hicks | 24 |
| Ryan Cartwright | Gary Bell | 24 |
| Malik Yoba | Bill Harken | 24 |
| Mahershala Ali | Nathan Clay | 12 |
| John Pyper-Ferguson | Stanton Parish | 10 |
| Jane Moffat | Sandra Bell | 8 |
| Kathleen Munroe | Danielle Rosen | 8 |
| Erin Way | Kat | 8 |
| Steve Byers | John Bennett | 7 |
| Rachael Crawford | Jeannie Harken | 6 |
| Summer Glau | Skylar Adams | 4 |
| Valerie Cruz | Kathy Sullivan | 4 |
| Elias Toufexis | Cornell Scipio | 4 |
| Kathleen Gati | Zahra Pirzad | 4 |
| Jameson Kraemer | Jeff 'Dumpy' Kowalka | 4 |
| Lauren Holly | Senator Charlotte Burton | 3 |
| Liane Balaban | Anna Levy | 3 |
| Sean Astin | Mitchel Morgan | 2 |
| Callum Keith Rennie | Don Wilson | 2 |
| Connor Price | Jason Miller | 2 |
| Gage Munroe | Tyler Hicks | 2 |
| Marnie Robinson | Woman in Blue Dress | 2 |
| Alex Paxton-Beesley | Megan Bates | 2 |
| Eileen Li | Nurse | 2 |
| C. Thomas Howell | Eli Aquino | 1 |
| Patrick Garrow | Dr. Harrison | 1 |
| Tatiana Maslany | Tracy Beaumont | 1 |
| Katie Douglas | Teenage Nina | 1 |
| Dylan Smith | Ted Asher | 1 |
| David Sparrow | Chief Handell | 1 |
| Andrew Moodie | Matt Seidel | 1 |
| Conrad Pla | Luke | 1 |
| Saad Siddiqui | Government Agent | 1 |
| Deborah Odell | Bonita | 1 |
| Neil Girvan | Pastor | 1 |
| Joe Pingue | Quinn | 1 |
| Kaniehtiio Horn | Trisha | 1 |
| Rebecca Mader | Griffin | 1 |
| Brent Spiner | Dr. Kern | 1 |
| Paulino Nunes | Agent Lou Persky | 1 |
| Kandyse McClure | Agnes | 1 |
| Shiva Negar | Guest | 1 |
| Peter Wingfield | James Collier | 1 |
| Will McCormack | Marcus Ayers | 1 |
| John White | Sam Girardi | 1 |
| Devon Graye | Matthew Hurley | 1 |
| Miranda Edwards | FBI Agent | 1 |
| Alaina Huffman | Sara Nelson | 1 |
| Lindsay Wagner | Dr. Vanessa Calder | 1 |
| Garret Dillahunt | Jonas Englin | 1 |
| Raoul Bhaneja | Vijaj Singh | 1 |
| Michael Reventar | Alonso | 1 |
| Marshall Williams | High School Guy | 1 |
| Conrad Coates | Claude | 1 |
| Sarah Manninen | Becky | 1 |
| Kyle Labine | Eddie | 1 |
| Kate Greenhouse | Patty Hicks | 1 |
| Carlos Gonzalez-Vio | Operative | 1 |
| Dmitry Chepovetsky | Gil | 1 |
| Rod Wilson | Nina's Dad | 1 |
| Phillip Jarrett | Dr. Lance Casey | 1 |
| Dean Armstrong | Milos Kosar | 1 |
| Lisa Ryder | Fiona | 1 |
| Greg Ellwand | Committee Chair | 1 |
| Tom Barnett | Eric Latreaux | 1 |
| Markus Parilo | Tough Guy | 1 |
| Morgan Kelly | Tommy | 1 |
| Lenno Britos | Pushed Man | 1 |
| Bill Lake | Transit Sergeant | 1 |
| Arnold Pinnock | Brian Kessler | 1 |
| Allie MacDonald | Lisa | 1 |
| Noah Reid | Adam Gordon | 1 |
| James Binkley | Transit Cop | 1 |
| James Binkley | Burly Patron | 1 |
| Gavin Fox | The Caretaker | 1 |
| Kimberly Huie | Natalie Young | 1 |
| Jeff Seymour | The Ghost | 1 |
| Peter DaCunha | Teddy | 1 |
| Michael Dyson | Cashier | 1 |
| Jamaal Grant | Senator's Assistant | 1 |
| Shane Daly | Kent Zelanski | 1 |
| Sean Baek | Ops | 1 |
| Nicki Whitely | Molly | 1 |
| Stefano DiMatteo | Vince | 1 |
| Louise Nicol | Elderly Woman | 1 |
| Patrick Stevenson | Detective | 1 |
| Nola Martin | Maggie Gordon | 1 |
| Paul Sun-Hyung Lee | Manager | 1 |
| Adrian Griffin | Coroner | 1 |
| Jason Gosbee | Mr. Howard | 1 |
| Scott Cavalheiro | Cute Guy | 1 |
| Marqus Bobesich | Klaus Kripke | 1 |
| Diana Salvatore | Magda Ryan | 1 |
| Ali Kazmi | Internist | 1 |
| Jimi Shlag | Detective | 1 |
| Daveed Louza | Binghamton Med Tech | 1 |
| Danny Waugh | Customs Official | 1 |
| Amanda Smith | Parish's Grandchild | 1 |
| Bobby Manning | Rasta | 1 |
| Brandon McGibbon | Reg | 1 |
| Tyler Kyte | Busker | 1 |
| Brian Kaulback | Dr. Jay Westman | 1 |
| Phil Morrison | Trucker | 1 |
| Penny Eizenga | Pedestrian | 1 |
| Adriano Sobretodo Jr. | Throat Singing Alpha | 1 |
| Adriano Sobretodo Jr. | Mimic Alpha | 1 |
| Adriano Sobretodo Jr. | Unassuming Man | 1 |
| Dwight Ireland | Analyst | 1 |
| Steve Lund | David Burton | 1 |
| Tre Smith | Agent Kubek | 1 |
| Nathan Stephenson | Bip | 1 |
| Glen Cross | Prisoner | 1 |
| Robbie Rox | Trucker | 1 |